New study compares the effects of red light with a low level with 0.01% atropine treatment to axial length and veiling in myopic children

One of the first author Xuena Pang, MD, under the direction of the first author, under the direction of red light in children reported myopia. They reported that a 6-month treatment showed that repeated use with red light (RLRL) with a low level was more effective than 0.01% atropine to control axial stretching and myopic progress in myopic children.¹

Pang and colleagues from the Department of Ophthalmology, the first connected hospital at Zhengzhou University, Zhengzhou, Henan, China, reported on their results in Ophthalmology and therapy.

“Myopia is more than just a frequent refraction.^2-4 It is important to find an effective treatment of myopia to control your development, since the condition is associated with an upward trend in prevalence, younger age and severity.^2-6Said.

Low -dosed atropine effectively stops the progression of myopia^7.8 Just like an increased exposure to natural light.^9-12 Only a randomized controlled study with atropine against RLRL was carried out,¹³ showed that RLRL was superior to myopia control 0.01% atropine. However, this study did not measure the choroidal parameters. In the current study, the effects of RLRL were examined on the treatment of children with myopia by examining the effectiveness differences between RLRL and 0.01% atropine for over 6 months, and examining the potential mechanism of RLRL and 0.01% atropine in delayed myopia in choroidal thick and choroidal blood flow Expanated.

Prospective, randomized and individually blind -controlled study

This examination comprised 91 children aged 6 to 12 years. The inclusion criteria were a spherical equivalent refraction (Ser) of -5.0 diopters (d) and –0.75 d or lower after bilateral astigmatism lower than 2.00 D, mostly corrected vision of 20/20 or better in monocular eyesight and intraocular pressure of 21 mmHG.

The children were randomized with RLRL or atropine of 0.01%for 6 months. The primary results included changes in the axial length (AL), ser- and choroidal parameters, which included the foveals, parafoveals and perifoveal wirer thickness as well as the foveal, parafoveal and perifoveal choroid.

The primary results were the changes in the al, serial and chorious parameters after 6 months.

The children treated with atropine received a drop of the drug at night before going to bed. Those who were treated with RLRL received a device that uses the Eyerising (Suzhou Xuanjia Photoelectric Technology), which uses a semiconductor laser diode to emit red light with a 650 ± 10 Nm wavelength from the pupil on the peel content of 1600 LX from the pupil on the light of 10 ± 3 mm Light value of 10 ± 3 mm. 2.0 ± 0.5 mW. The children received slight treatment every time twice a day with at least 4 hours between the treatments. The parents/legal guardians administered the easy treatment.

Changes after 6 months

Pang and colleagues reported that in the 6-month evaluation, the respective changes of the children in RLRL and atropine were randomized in the AL (-0.18, 0.01) compared to 0.13 mm (0.05, 0.24) (0.01) (0.05, 0.24) () (0.05) (-0.18, 0.01) (0.05, 0.24) ()PP

In the children who were treated with RLRL and atropine of 0.01%, the respective changes in the foveals, parafoveal and perifoveal choroid thickness were 36.38 µm (14.05, 65.39), 31.04 µm (4,09, 59.35) and 28.48 µm (5.35, 5.15) and 28.48 µm (5.35, 5.15). 9.36), 3.52 µm ( – 10.24, 14.45) and 6.14 µm ( – 5.21, 15.69) ( – ( – 5.21, 15.69) (P 

In addition, the respective foveals, parafoveals and perifoveal choroidal vascular volume volume with the two treatments were 0.01 μm³ (0.00, 0.02), 0.05 μm³ (0.02, 0.09) and 0.20 μm³ (0.05, 0.30) compared to 0.00 μm³ ( – 0.00, 0.01), 0.01 μm³ ( – 0.02, 0.03) and 0.01 μm³ ( – 0.06, 0.09) ( –P 

The researchers proposed that RLRL therapy improves choroidal blood flow, which improves the oxygen supply and the nutrient availability of scleral hypoxia and delays axial growth. They felt that studies are necessary to understand the exact mechanisms of RLRL therapy.

The authors came to the conclusion: “In children with myopia between the ages of 6 and 12, RLRL became 0.01% atropine in the central level of the Axial European and myopia progression. 0.01% atroping group. “

References:

1. Pang X, Fu a, Zheng G, et al. The effect of a repeated red light with a low level compared to 0.01% atropine treatment on the axial length and the choroidal parameters in children with myopia. Ophthalmol Ther. 2025; 14: 1739–1754. https://doi.org/10.1007/s40123-025-01169-0

2. Pan CW, Ramamurthy D, saw SM. Worldwide prevalence and risk factors for myopia. Ophthalm Physiol Opt . 2012; 32: 3–16. https://doi.org/10. 1111/J.1475-1313.2011.00884.X.

3. Wu PC, Huang Hm, Yu HJ, Fang PC, Chen ct. Epidemiology of myopia. Asia Pac J Ophthalmol (Phila).2016; 5: 386–93. https://doi.org/10.1097/apo.00000000000236.1752

4. Holden Ba, Fricke Tr, Wilson there, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 to 2050. Ophthalmology . 2016; 123: 1036–42. https://doi.org/10.1016/j.ophtha.2016.01.006.

5. Morgan IG, NOTO-Matsui K, saw SM. Myopia. Lancet. 2012; 379 (9827): 1739–48. https://doi.org/10.1016/s0140- 6736 (12) 60272-4.

6. Haarman Aeg, deshoven Ca, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver Ccw. The complications of myopia: a review and meta -analysis. Invest ophthalmol Vis Sci. 2020; 61: 49. Https://doi.org/10.1167/iovs.61.4.49.

7. Wu J, Lu ad, Zhang LP, Zuo Yx, Jia Yp. Investigation of the clinical result and the forecast of pediatric core bond factor acute myeloic leukemia. Zhonghua xue ye xue za zhi. 2019; 40: 52–7. https://doi.org/10.3760/cma.j.issn.0253-2727.2019.01.010.

8. Huang J, Wen D, Wang Q, et al. Comparison of 16 interventions for myopia control in children: a network meta-analysis. Ophthalmology. 2016; 123: 697–708. https: // doi. Org/10.1016/J.ophtha.2015.11.010.

9. Rose Ka, Morgan IG, IP J, et al. The activity outdoors reduces the prevalence of myopia in children. Ophthalmology. 2008; 115: 1279–85. https://doi.org/10.1016/j.ophtha.2007.12.019.

10. French an, Ashby RS, Morgan IG, Rose Ka. Time outdoors and the prevention of myopia. Exp eyes res. 2013; 114: 58–68. https://doi.org/10.1016/J.exer.2013.04.018.

11. He M, Xiang F, Zeng y, et al. Effect of the time outdoors at school on the development of myopia among children in China: a randomized clinical study. Jama. 2015; 314: 1142–8. https://doi.org/10.1001/jama.2015.10803.

12. Wu PC, Chen CT, Lin KK, et al. Myopia prevention and light intensity outdoors in a school -based cluster randomized study. Ophthalmology. 2018; 125: 1239-50. https://doi.org/10.1016/j.ophtha.2017.12.011.

13. Chen Y, Xiong R, Chen X, et al. Comparability of repeated red light and low -dosed atropine for myopia control: a randomized controlled study. Translate Vis Sci Technol.2022; 11: 33. Https://doi.org/10.1167/tvst.11.10.33.